Recent Articles

• Hong, J.-K., Yeom, M., Hwang, H.-Y., Mun, E., Woo, J.-H., Kim, Y., Shin, J.-H. Lee, Y., Kim, D., Guengerich. F.P., and Choi, J.-Y. (2025, in press) Chem.-Biol. Interact. “Four Germline POLH Variants, Including Two Found in Skin Tumors, Impair DNA Polymerase hFunction and Cellular Tolerance to UV Radiation and Cisplatin.”
• McCarty, K.D., and Guengerich, F.P. (2025) J. Biol. Chem. 301, 108168. “Liver Fatty Acid Binding Protein FABP1 Transfers Substrates to Cytochrome P450 4A11 for Catalysis.”
• Koinuma, K., Noto, K., Morita, T., Uekusa, Y., Kikuchi, H., Shimoji,  M., Seki, H., Yamazaki, H., Guengerich, F. P., Nakamura, K., Yamamoto, K., Imaoka, A., Akiyoshi, T., and Ohtani, H. (2025) J. Pharmaceut. Sci. 114, 849-856. “Kinetics of the Inhibition of CYP3A4 and CYP2C19 Activity by Jabara Juice and Identification of the Responsible Inhibitory Components.”
• Tomar, R., Ghodke, P.P., Patra, A., Smyth, E., Ponatarelli, A., Copp, W.  Guengerich, F.P., Chaput, J.J., Wilds, C.J., Stone, M.P., and Egli, M. (2024) Biochemistry 63, 2425-2439. “DNA Replication Across a-L-(3′-2′)-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta.”
• Tateishi, Y., McCarty, K.D., Martin, M.V., Yoshimoto, F.K., and Guengerich, F.P. (2024) Angew. Chem., Int. Ed. 63, e202406542. “Roles of Ferric Peroxide Anion Intermediates (Fe3+O2¯) in Cytochrome P450 19A1 Steroid Aromatization and a Cytochrome P450 2B4 Secosteroid Model.”
• Hargrove, T.Y., Lamb, D.C., Wawrazk, Z., Hull, M.T., Kelloy, S.L., La Scola, B., Guengerich, F.P., and Lepesheva, G.I. (2024) J. Med. Chem. 67, 7443-7457. “Identification of Potent and Selective Inhibitors of Acanthamoeba: Structural Insights into Sterol 14a-Demethylase as a Key Drug Target.”
• Uehara, S., Murayama, N., Higuchi, Y., Shimizu, M., Suemizu, H. Guengerich, F.P., and Yamazaki, H. (2024) Chem. Res. Toxicol. 37, 671-674. “In Vivo and
  In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH Cells.”
• Tateishi, Y., McCarty, K.D., Martin, M.V., and Guengerich, F.P. (2024) ACS Catalysis. 14, 2388-2394. “Oxygen-18 Labeling Defines a Ferric Peroxide (Compound 0) Mechanism in the Oxidative Deformylation of Aldehydes by Cytochrome P450 2B4.”
• Tateishi, Y., Webb, S.N., Li, B., Liu, L., Lindsey Rose, K., Leser, M., Patel, P., and Guengerich, F.P. (2024) J. Biol. Chem. 300, 105688. “Proteomics, Modeling, and Fluorescence Assays Delineate Cytochrome b₅ Residues Involved in Binding and Stimulation of Cytochrome P450 17A1 Lyase.”
• McCarty, K.D., Tateishi, Y., Hargrove, T.Y., Lepesheva, G.I., and Guengerich, F.P. (2024) Angew. Chem., Int. Ed. 320231771 “Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in Cytochrome P450 51A1 Sterol 14a-Demethylation.”
• McCarty, K.D., Liu, L., Tateishi, Y., Wapshott-Stehli, H.L., and Guengerich, F.P. (2023) J. Biol. Chem. 300, 105495. “The Multistep Oxidation of Cholesterol to Pregnenolone by Human Cytochrome P450 11A1 is Highly Processive.”
• Nagayoshi, H. Murayama, N., Kim, V., Kim, D., Takenaka, S., Yamazaki, H., Guengerich, F.P., and Shimada T. (2023) Chem. Res. Toxicol. 36, 1778-1788. “Oxidation of Naringenin, Apigenin, and Genistein by Human P450 1B.1 and Scutallaria P450 82D.1.
• Kojima, M., Machida, K., Cho, S., Watanabe, D., Seki, H., Shimoji, M., Imaoka, A., Yamazaki, H., Guengerich, F.P., Nakamura, K., Yamamoto, K., Akiyoshi, T., and Ohtani, H. (2023) Xenobiotica 53, 357-365. “The Influence of Temperature on the Metabolic Activity of CYP2C9, CYP2C19, and CYP3A4 Genetic Variants.”
• Spalenkova, A., Ehrlichova, M., Wei, S., Guengerich, F.P., and Soucek, P. (2023) J. Steroid Biochem. Mol. Biol. 232,106354. “Effects of 7-Ketocholesterol on Tamoxifen Efficacy in Breast Carcinoma Cell Line Models in vitro.”
• Glass, S.M., Tateishi, Y., Guengerich, F.P., and Wang H.-J. (2023) Arch. Biochem. Biophys 743, 109669. “3,4-Desaturation of Retinoic Acids by Cytochrome P450 27C1 Prevents P450-Mediated Catabolism.”
• McCarty, K.D., Sullivan, M.E., Tateishi, Y., Hargrove, T.Y., Lepesheva, G.I., and Guengerich, F.P. (2023) J. Biol. Chem.299, 104841. “Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1.”
• Jian, J.Y., McCarty, K.D., Byl, J.W., Guengerich, F.P., Neuman, K.C. and Osheroff, N. (2023) Nucl. Acids Res. 51, 3888-3902. “Basis for the Discrimination of Supercoil Handedness During DNA Cleavage by Human and Bacterial Type II Topoisomerases.”
• Yeom, M., Hong, J.-K., Shin, J.-H., Lee, Y., Guengerich, F.P., and Choi, J.-Y. (2023) Int. J. Mol. Sci. 24, 5198. “Identification of Three Human POLH Germline Variants Defective in Complementing the UV- and Cisplatin-Sensitivity of POLH-Deficient Cells.”
• Lee, S.-G., Kim, V., Lee, G.-H., Kim, C., Jeong, E., Guengerich, F.P., and Kim, D. (2023) J. Inorg. Biochem. 240, 112085 “Hydroxylation and Lyase Reactions of Steroids Catalyzed by Mouse Cytochrome P450 17A1 (Cyp17a1).”

Review Articles

• Guengerich, F.P. (2024) J. Biol. Chem. 300, 105625. “Reflection: Ninety-eight Semesters of Cytochrome P450 Enzymes and Related Topics—What Have I Taught and Learned?”
• Guengerich, F.P. (2024) Pharmacol. Rev. 76, 1104-1132. “Roles of Human Cytochrome P450 Enzymes in Drug Metabolism.”
• Rendic, S.P., and Guengerich, F.P. (2024) Arch. Toxicol. 98, 1581-1628. “Bioactivation of Drugs to Potentially Toxic Products Catalyzed by Human Drug-Metabolizing Enzymes.”
• Guengerich, F.P., Tateishi, Y., McCarty, K.D., and Yoshimoto, F.K. (2024) Int. J. Mol. Sci.25, 9020. “Recent Updates on Mechanisms of Cytochrome P450 Catalysis of Complex Steroid Oxidations.”
• Guengerich, F.P. (2024) Drug Metab. Dispos. 52, 493-497. “Cytochrome P450 Enzymes as Drug Targets in Human Disease.”
• Guengerich, F.P., Tateishi, Y., and McCarty, K.D. (2023) Med. Chem. Res. 32, 1263-1277. “Mechanisms of Cytochrome P450 Catalysis: C-C Bond Cleavage Reactions and Roles of Iron-Oxygen Complexes.
• Guengerich, F.P., McCarty, K.D., Tateishi, Y., and Liu, L., (2023) Methods Enzymol. 689, 39-63. “Steroid 17alpha-Hydroxylase/17,20-Lyase (Cytochrome P450 17A1).”
• Guengerich, F.P. (2023) Drug Metab. Dispos. 51, 99-104. “Drug Metabolism: A Half-Century Plus of Progress, Continuing Needs, and New Opportunities.”